autogenous vaccines/autovaccines in horse medicine

Introduction about autogenous vaccines/autovaccines

Treatment of infectious diseases by use of autogenous vaccines has a long tradition in veterinary medicine. Unlike antibiotics, which target the micro-organism directly, autogenous vaccines pursue the strategy to gently help the immune system of an infected animal to cope with an infectious disease causing micro-organism. Consequently, autovaccination is a method to specifically modulate the immune system of the infected animal by offering a tailored antigen (i.e. the autogenous vaccine). Autogenous vaccines may be used for prophylaxis (i.e. like bacterins) or for the treatment of infections already present and manifest diseases. Obligate requirement is that the disease causing micro-organism (i.e. the etiologic agent) is available (within any specimen, e.g. swab, tissue, faeces, etc.). Application form may vary, per oral, intra nasal, intra vaginal and subcutaneous applications are possible, depending on the type of disease to be prevented/treated.

Infectious diseases in horses

Horses maybe subject to a large variety of different pathogenic micro-organism. While in a number of cases treatment with an antimicrobial drug might provide relief for the infected animal, antimicrobial therapy may fail in other cases. Treatment failure and repeated therapy is a source of potential harm for the animal, making it weak and triggering development of both, antimicrobial resistance and chronic, incriminating disease. Infections of the reproductive tract most likely causes temporal infertility, making expensive treatments necessary.

Autogenous vaccines/autovaccines as alternatives

In a recent article by Nolte et al (2004), printed in a German veterinary journal, we have provided data regarding the effectiveness of autogenous vaccines in the treatment of disease of the respiratory tract in horses {include reference}. Our data show, that while attempts to control infection by use of antibiotics may not be successful, autogenous immune stimulation by autovaccination is a highly promising alternative. Similar results have been observed in the treatment of metritis (paper in preparation).

References:

Patents:

WEISS, H.-E, WEISS, H., NOLTE, O. & SONNTAG, H.-G. (1998):
Deutsches Patent Nr. 198 60438
SONNTAG, H.-G., NOLTE, O., WEISS, H. & WEISS, H.-E. (2004):
Europäisches Patent EP 1 140 160 B1: Verfahren zur Herstellung von Autovakzinen zur Behandlung von Chalymdiosen von Säugetieren und Menschen. Internationale Veröffentlichungsnummer WO2000/038712 (06.07.2000 Gazette 2000/27).

Publications:

NOLTE, O., MORSCHER, J., WEISS, H.-E. & SONNTAG, H.-G. (2001):
Therapeutic autovaccination in cattle for the treatment of Actinomyces pyogenes mediated metritis. Vaccine 19(23-24):3146-3153

NOLTE, O., WEISS, H.-E, SONNTAG, H.-G. & HARTMANN, S. (2004):
Homologe Autovakzination in der Behandlung von Infektionskrankheiten der Pferde - Ergebnisse einer retrospektiven Erhebung. Tierärztl. Umschau 59:315-320 (download pdf)
(authors translation:"Homologous autovaccination for the treatment of infectious diseases in horses - results of a retrospective survey")
Der Artikel wurde vorgestellt und diskutiert in Der Praktische Tierarzt 89 Ausgabe 5 2005
The article has been discussed in "Der Praktische Tierarzt", volume 89, issue 5, p:339 in 2005.

WEISS, H.-E, NOLTE, O., Bracknies, S., PFEFFERLE, Th. & HARTMANN, S. (2007):
Autovakzine (autogene Autovakzination) in der Behandlung von Pferdekrankheiten. Tierärztl. Umschau 62:659-666 (download pdf)
(authors translation:"Autogenous vaccines (autogenous vaccination) for the treatment of horse specific infectious diseases.")

For a complete list of papers published by H.-E. Weiss please use this link (opens a new window)
For a complete list of papers published by O. Nolte please use this link (opens a new window), or download a pdf-file

Credits

Responsible for the content: Hans-Erich Weiss (DVM) [Contact-Information]
Design and technical realization: Oliver Nolte (Ph.D.) [imprint/Impressum]

The image shown at the beginning of this page was kindly provided by Dr. T. Pfefferle (Mengen, Germany) and was modified to fit the requirements of this website. The picture shows a mare with its foal. Successful insemination of the mare was possible when a yeast infection was positively influenced by homologous autovaccination.

The pdf files are offered for download with permission of Terra Verlag (Tierärztliche Umschau).

Copyrights

The complete page and any content therein (text, pictures, etc.) are protected by copyrights even if this is not explicitly mentioned in/on a particular part of this site.

Inquiries and comments about autovaccines please send to H.-E. Weiss (weiss-at-autovaccine.de // Hans-Erich.Weiss-at-cvuaka.bwl.de)
Any other questions or comments may be send to O. Nolte (webmaster-at-coleopterologe.de)

this website is listed in:

List of available autovaccines, autogenous vaccines, and autogenous biologicals *
	autogenous vaccine against	species	indication and application route
1.	E. coli diarrhea	horse	therap.-peroral
1a.	- ß-hemolysing
	- mucoid
	- R-forms
1b.	in combination with Proteus ssp. Bacillus cereus, Pseudomonas ssp.
2.	Infections with Pasteurella sp.	horse	therap. & prophyl. sc / or i.n.
3.	Infections with Chlamydia psittaci or Chlamydophila ssp. (see: DPat.-Nr. DE198 604 38; EP 1140160 B1	horses	therap. & prophyl.-sc
4.	Infections with Pseudomonas sp. Pseudomonadaceae (Non-fermenting Gram negative rods/Stenotrophomonas and others.)
4a.	Bronchopneumonia	horse	therap.-sc
4b.	Throat-/nose-/ear infections and ceratoconjunctivitis	horse	therap.- peroral + sc
5.	pyodermia caused by Staphylococcus aureus, S. intermedius, S. hyicus etc	horse	therap.-sc
6.	Papillomatosis (Warts) and Equine Sarcoid (see: D-Pat.Application.: 100 21 433; Int.Pat.Application.:WO 0024420)	horse, donkey, zebra	therap.-sc
7.	Chlamydia/Actinomyces (Arcanobacterium) pyogenes (see patents under 3. as well as Nolte et al 2001)	horse	proph.-sc
8a.	Rhodococcus equi (Corynebacterium equi)	in foal	sc for prophylaxis in foals
8b.		mares and horses, donkey, zebra	therap. u. prophyl. sc
9.	Streptococcus equi, zooepidemicus, equisimilis	horse, donkey, zebra	prophyl.-sc/ therap.-sc
10.	Bacillus cereus	horse, donkey, zebra	therap.-sc
11.	Bacillus cereus/E.coli	horse, donkey, zebra	therap.-peroral
12.	Corynebacterium sp. [Actinomyces(Arcanobacterium)] metritis	in foal mares	therap./prophyl. sc
13.	Klebsiella sp.	horse	therap.-sc/peroral
14.	Microsporum ssp., Trichophyton ssp. (Dermatomycosis)	horse, donkey, zebra	therap.-sc/peroral
15.	Yeast (e.g. Candida ssp.) (Metritis)	mares	therap./prophyl.sc

Autogenous vaccines (horses/mares/foals)